Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)
نویسندگان
چکیده
This review provides a comprehensive overview of natural product ligands RAR-related orphan receptors (RORs).
منابع مشابه
Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism
In this overview, we provide an update on recent progress made in understanding the mechanisms of action, physiological functions, and roles in disease of retinoic acid related orphan receptors (RORs). We are particularly focusing on their roles in the regulation of adaptive and innate immunity, brain function, retinal development, cancer, glucose and lipid metabolism, circadian rhythm, metabol...
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The last few years have witnessed a rapid increase in our knowledge of the retinoid-related orphan receptors RORalpha, -beta, and -gamma (NR1F1-3), their mechanism of action, physiological functions, and their potential role in several pathologies. The characterization of ROR-deficient mice and gene expression profiling in particular have provided great insights into the critical functions of R...
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ژورنال
عنوان ژورنال: Natural Product Reports
سال: 2021
ISSN: ['0265-0568', '1460-4752']
DOI: https://doi.org/10.1039/d0np00047g